The relationship between 8-catenin and patient survival in colorectal cancer systematic review and meta-analysis

8-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a metaanalysis was performed to assess the prognostic value of 8-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between 8-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear 8-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous 8-catenin expression was associated to poor OS. In conclusion, 8-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.

Automated summary

The meta-analysis concluded that high nuclear expression of 8-catenin is associated with poor prognosis in terms of disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) for colorectal cancer (CRC) patients, while low membranous expression of 8-catenin is related to poor OS. Further validation with larger tissue cohorts and patient data is needed to confirm these findings.