Recent advances in non-specific immune memory against bovine tuberculosis

Bovine tuberculosis is an important worldwide disease mainly related to cattle, although it also affects other mammals, including humans. In recent years, there have been considerable advances in the knowledge of the immune response mechanisms underlying the interaction of Mycobacterium bovis, the main agent of bovine tuberculosis, with its hosts. In this review we describe the most recent findings on the cattle immune response to M. bovis, particularly regarding trained innate immune responses and ?6 T cells, that could support the development of vaccines and diagnostic tools to control this disease.

Automated summary

Recent research has made significant advances in understanding the immune response of cattle to Mycobacterium bovis, the main agent of bovine tuberculosis. Focus has been on trained innate immune responses and ?6 T cells, with the potential to support the development of vaccines and diagnostic tools for disease control.