Therapeutic Potential of Digital Nerve Block in Rheumatoid Arthritis Patients A Clinical and Sonographic Prospective Study

Background: This study attempted to test the effectiveness of digital nerve block (DNB) in active rheumatoid arthritis (RA) joints with respect to local disease control. Methods: The study included 83 RA patients aged 18 years or above and diagnosed, after American College of Rheumatology/European League Against Rheumatism criteria 2010, with bilateral proximal interphalangeal (PIP) arthritis. PIPs were examined by European League Against Rheumatism-outcome measures in rheumatoid arthritis clinical trials scoring system at 0, 2, and 8 weeks. Visual analog scales for each hand were also done at the same intervals. DNBs of the second and third PIPs were performed to the dominant hand in 50% of participants. The other hand was used as a control, and saline was injected in the same level at the control side. Results: At 2 weeks and 8 weeks intervals, the active side showed significantly less clinical and ultrasound scores when compared to the control side and the baseline values. The mean OMERACT score for the active hand dropped from 3.37 +/- 1.43 at 0 time to 2.31 +/- 1.66 after 2 weeks and 2.55 +/- 1.43 at 8 weeks (P<0.001). Also, visual analog scale decreased from 59 at 0 time to 41 at 2 weeks and 43 at 8 weeks (P<0.001). The amelioration was greater when the active side was the dominant one. The injected PIPs showed maximum improvement at 2 weeks. Improvement was more significant in the second PIP. Early patients achieved better outcomes. Conclusion: DNB is a new promising therapy for RA. It can control pain and inflammation of the PIPs. It has relatively short-term effect, yet it could limit escalation of systemic treatment plans.

Automated summary

The study showed that DNB is effective in controlling local disease in active RA joints, with significant improvement in clinical and ultrasound scores at 2 and 8 weeks. Treatment effects were more pronounced in the dominant hand, with maximum improvement observed at 2 weeks in the injected PIPs, particularly in the second PIP. Early intervention led to better outcomes.