Single Dose of an mRNA Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Vaccine Is Associated With Lower Nasopharyngeal Viral Load Among Nursing Home Residents With Asymptomatic Coronavirus Disease 2019 (COVID-19)

Article Microbiology

Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test

Stephen Young et al.

Summary: The BD Veritor System for Rapid Detection of SARS-CoV-2 nucleocapsid antigen showed varied performance in different DSO ranges compared to PCR testing, with PPA values below 100%. However, Veritor demonstrated high agreement with Sofia 2 in detecting SARS-CoV-2.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19 A Randomized Clinical Trial

Robert L. Gottlieb et al.

Summary: The study showed that treatment with bamlanivimab and etesevimab was significantly associated with a reduction in SARS-CoV-2 viral load at day 11 in nonhospitalized patients with mild to moderate COVID-19, compared to placebo. However, bamlanivimab monotherapy did not show a significant reduction in viral load. Ongoing clinical trials will focus on assessing the clinical benefits of antispike neutralizing antibodies in COVID-19 patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Covid-19 vaccination: What’s the evidence for extending the dosing interval?

Gareth Iacobucci et al.

BMJ-British Medical Journal (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Michael A. Johansson et al.

Summary: The study suggests that more than half of COVID-19 transmission may come from asymptomatic individuals, highlighting the importance of measures beyond identifying and isolating symptomatic cases in controlling the spread of the virus.

JAMA NETWORK OPEN (2021)

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Article Infectious Diseases

Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study

Michael Marks et al.

Summary: The viral load of index cases is a key driver of SARS-CoV-2 transmission, while the viral load of contacts at baseline is strongly associated with the risk of developing symptomatic COVID-19 and shortening the incubation period in a dose-dependent manner.

LANCET INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal