Journal
CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 6, Pages E1365-E1367Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab263
Keywords
SARS-CoV-2; COVID-19; viral load; cycle threshold; asymptomatic
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A single dose of mRNA SARS-CoV-2 vaccine has been shown to lower the viral load in asymptomatic COVID-19 patients, potentially aiding in controlling outbreaks as viral load is linked to transmission.
In nursing home residents with asymptomatic COVID-19 diagnosed through twice-weekly surveillance testing, single-dose BNT162b2 vaccination (Pfizer-BioNTech) was associated with -2.4 mean log 10 lower nasopharyngeal viral load than detected in absence of vaccination (P=.004). Since viral load is linked to transmission, single-dose mRNA SARS-CoV-2 vaccination may help control outbreaks.
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