4.7 Review

Facts and Hopes in Multiple Myeloma Immunotherapy

Journal

CLINICAL CANCER RESEARCH
Volume 27, Issue 16, Pages 4468-4477

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-20-3600

Keywords

-

Categories

Funding

  1. NCI [K08CA252174]

Ask authors/readers for more resources

One hallmark of cancer is the ability of tumor cells to evade and suppress the immune system, with multiple myeloma being a prime example. Decades of research have led to the discovery of various therapeutic agents, including those that alter immune interactions to combat myeloma. Progress in immunotherapy offers hope for a potential cure for this deadly disease.
Among the hallmarks of cancer is the ability of neoplastic cells to evade and suppress immune surveillance to allow their growth and evolution. Nowhere is this as apparent as in multiple myeloma, a cancer of antibody-producing plasma cells, where a complex interplay between neoplastic cells and the immune microenvironment is required for the development and progression of disease. Decades of research has led to the discovery of a number of therapeutic agents, from cytotoxic drugs to genetically engineered cells that mediate their anti-myeloma effects at least partially through altering these immune interactions. In this review, we discuss the history of immunotherapy and current practices in multiple myeloma, as well as the advances that promise to one day offer a cure for this deadly disease.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available