4.7 Article

Artificial Intelligence in Hypertension Seeing Through a Glass Darkly

Journal

CIRCULATION RESEARCH
Volume 128, Issue 7, Pages 1100-1118

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.121.318106

Keywords

artificial intelligence; blood pressure; clinical trial; hypertension; machine learning

Funding

  1. Medical Research Council [MR/M016560/1]
  2. British Heart Foundation [PG/12/85/29925, CS/16/1/31878, RE/18/6/34217]
  3. Health Data Research UK [HDR-5012]
  4. Chief Scientist Office, Scotland
  5. UK Research and Innovation Strength in Places Fund

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Hypertension remains a major modifiable cause of mortality worldwide, and transformative solutions are needed to reduce the burden of the disease. Artificial intelligence and machine learning may be the route to this transformation, but are still in their early stages in healthcare, requiring numerous challenges to be overcome.
Hypertension remains the largest modifiable cause of mortality worldwide despite the availability of effective medications and sustained research efforts over the past 100 years. Hypertension requires transformative solutions that can help reduce the global burden of the disease. Artificial intelligence and machine learning, which have made a substantial impact on our everyday lives over the last decade may be the route to this transformation. However, artificial intelligence in health care is still in its nascent stages and realizing its potential requires numerous challenges to be overcome. In this review, we provide a clinician-centric perspective on artificial intelligence and machine learning as applied to medicine and hypertension. We focus on the main roadblocks impeding implementation of this technology in clinical care and describe efforts driving potential solutions. At the juncture, there is a critical requirement for clinical and scientific expertise to work in tandem with algorithmic innovation followed by rigorous validation and scrutiny to realize the promise of artificial intelligence-enabled health care for hypertension and other chronic diseases.

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