4.6 Article

Electrochemical Dehydrogenative C(sp2)-H Amination

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 30, Pages 8008-8012

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202100960

Keywords

amination; carbazole; electrochemistry; heterocycles; nitrenium ion

Funding

  1. DFG [AN 1064/4-1]
  2. Boehringer Ingelheim Foundation (Plus 3)

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A transition-metal-free direct electrolytic C-H amination involving an electrochemically generated nitrenium ion intermediate has been developed. The electrosynthesis takes place in the absence of any organoiodine catalysts and is enabled by an in situ generated electrolyte. A novel, efficient intramolecular and intermolecular C-H amination has been demonstrated using a simple reaction setup.
A transition-metal-free direct electrolytic C-H amination involving an electrochemically generated nitrenium ion intermediate has been developed. The electrosynthesis takes place in the absence of any organoiodine catalysts and is enabled by an in situ generated electrolyte. A novel, efficient intramolecular and intermolecular C-H amination has been demonstrated using a simple reaction setup.

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