Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 39, Pages 10186-10192Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202101086
Keywords
aggregation induced emission; biosensors; sequence-defined oligomers; solid phase polymer; supramolecular synthesis
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Funding
- DFG through the collaborative research center 1093
- Projekt DEAL
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The use of AIE luminophore for conjugation onto supramolecular ligands enables the detection of ligand binding. The positioning of the luminophore within the ligand scaffold strongly affects the AIE properties. Studies demonstrate that the position within the ligand structure significantly influences the performance of AIE.
A luminophore with aggregation-induced emission (AIE) is employed for the conjugation onto supramolecular ligands to allow for detection of ligand binding. Supramolecular ligands are based on the combination of sequence-defined oligo(amidoamine) scaffolds and guanidiniocarbonyl-pyrrole (GCP) as binding motif. We hypothesize that AIE properties are strongly affected by positioning of the luminophore within the ligand scaffold. Therefore, we systematically investigate the effects placing the AIE luminophore at different positions within the overall construct, for example, in the main or side chain of the olig(amidoamine). Indeed, we can show that the position within the ligand structure strongly affects AIE, both for the ligand itself as well as when applying the ligand for the detection of different biological and synthetic polyanions.
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