Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 57, Issue 3, Pages 261-265Publisher
SPRINGER
DOI: 10.1007/s10593-021-02902-w
Keywords
3-amino-5-methylisoxazole; alpha-ketoglutaric acid; [1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acid; multicomponent reaction
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Funding
- National Research Foundation of Ukraine [2020.02/0023]
- National Academy of Sciences of Ukraine [0119U100727]
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In this study, [2-aryl-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acids and their esters were synthesized via a three-component reaction involving alpha-ketoglutaric acid or its diethyl ester, 3-amino-5-methylisoxazole, and aromatic aldehydes.
[2-Aryl-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acids and their esters were synthesized by the three-component reaction of alpha-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes.
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