Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties

Isotope-labeled antiviral drug Triazavirin containing H-2, C-13, and N-15 atoms in its structure has been synthesized. (CH3I)-C-13-H-2 and (KSCN)-C-13 served as donors of C-13 isotopes. The use of C-13-MeI containing H-2 atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The N-15 atoms were incorporated using N-15-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting H-2(3),C-13(2),N-15(3)-Triazavirin was characterized by NMR spectroscopy.

Automated summary

The isotope-labeled antiviral drug Triazavirin containing H-2, C-13, and N-15 atoms in its structure has been synthesized, with donors including (CH3I)-C-13-H-2 and (KSCN)-C-13. The incorporation of deuterium labels and N-15 atoms was achieved using specific methods, resulting in the characterization of H-2(3),C-13(2),N-15(3)-Triazavirin through NMR spectroscopy.