Journal
CHEMISTRY LETTERS
Volume 50, Issue 7, Pages 1412-1415Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.210204
Keywords
Oxidation responsive; Oligonucleotide; Boronic acid
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Funding
- KOSE cosmetology research foundation
- Uehara Memorial Foundation
- JSPS Research Fellowships for Young Scientists
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Oxidation-responsive oligonucleotides can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. The postmodification approach described here involves introducing a 4-boronobenzyl group to a phosphate group at the 5'-terminal of an ON using the reactivity of diazo compounds.
Oxidation-responsive oligonucleotides (ONs) can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. Herein, we describe a postmodification approach to constructing an oxidation-responsive ON that takes advantage of the reactivity of diazo compounds in introducing a 4-boronobenzyl group to a phosphate group at a 5'-terminal of an ON.
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