Journal
CHEMISTRY LETTERS
Volume 50, Issue 6, Pages 1254-1258Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.210103
Keywords
Flow chemistry; Kinetics; ReactIR
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This paper proposes a technical approach to determine the conditions of continuous flow synthesis from batch data, by directly detecting acid chloride formation and calculating residence time. With the assistance of simulation method, sequential flow operations can be completed in approximately 1 minute.
This paper proposes a technical approach for seamlessly setting the conditions of continuous flow synthesis from batch data. We directly detected the acid chloride formation from Fmoc-L-Phe-OH in batch using the in-line monitoring technology ReactIR and logically calculated the residence time under continuous flow conditions based on kinetic study. Assisted by this simulation method, the sequential flow operations, which consist of acid chloride formation from Fmoc-L-Phe-OH, cooling and coupling with Fmoc-L-Phe-Cl and H2N-L-Phe-OMe, were completed in approximately 1 min.
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