Journal
CHEMISTRY & BIODIVERSITY
Volume 18, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000949
Keywords
eremophilane sesquiterpenes; benzene derivatives; Microdiplodia; ECD calculations; antiproliferative effect
Funding
- National Key Research and Development Program of China [2017YFD0201100, 2018YFD0201000]
- National Natural Science Foundation of China [31572043, 21602109]
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Three new eremophilane sesquiterpenes phomadecalins G-I and two new benzene derivatives microdiplzenes A and B, along with nine known compounds, were isolated from an endophytic fungus. Their structures were elucidated by HR-ESI-MS and NMR, and the absolute configurations were determined using ECD calculations. All compounds were evaluated for antimicrobial activities and antiproliferative effects on human gastric cancer cell lines.
Three new eremophilane sesquiterpenes phomadecalins G-I (1-3) and two new benzene derivatives microdiplzenes A and B (12 and 13), together with nine known eremophilane sesquiterpenes (4-11 and 14) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR-ESI-MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC-823).
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