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Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: Comparison with fluoxetine and quinidine
KM Bertelsen et al.
DRUG METABOLISM AND DISPOSITION (2003)
Mechanism-based inactivation of human recombinant P4502C9 by the nonsteroidal anti-inflammatory drug suprofen
JP O'Donnell et al.
DRUG METABOLISM AND DISPOSITION (2003)
Spin forbidden chemical reactions of transition metal compounds. New ideas and new computational challenges
R Poli et al.
CHEMICAL SOCIETY REVIEWS (2003)
Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine
L Labbe et al.
XENOBIOTICA (2003)
The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
PB Danielson
CURRENT DRUG METABOLISM (2002)
Clinical importance of the cytochromes P450
DW Nebert et al.
LANCET (2002)
What factors affect the regioselectivity of oxidation by cytochrome P450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction
SP de Visser et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory
S Shaik et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2002)
N-H and α(C-H) bond dissociation enthalpies of aliphatic amines
J Lalevée et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Oxidizing species in the mechanism of cytochrome P450
PRO de Montellano et al.
NATURAL PRODUCT REPORTS (2002)
Theoretical study on kinetic isotope effects in the C-H bond activation of alkanes by iron-oxo complexes
K Yoshizawa
COORDINATION CHEMISTRY REVIEWS (2002)
Isoniazid is a mechanism-based inhibitor of cytochrome P-450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes
X Wen et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Biotransformation reactions of five-membered aromatic heterocyclic rings
DK Dalvie et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2002)
Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase
CR Nishida et al.
DRUG METABOLISM REVIEWS (2002)
N-oxidative transformation of free and N-substituted amine functions by cytochrome P450 as means of bioactivation and detoxication
P Hlavica
DRUG METABOLISM REVIEWS (2002)
Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes
PF Hollenberg
DRUG METABOLISM REVIEWS (2002)
A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study
G Pandey et al.
CHEMICAL COMMUNICATIONS (2002)
A theoretical study of the dynamic behavior of alkane hydroxylation by a compound I model of cytochrome P450
K Yoshizawa et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
The structure and spin coupling of catalase compound I: A study of noncovalent effects
MT Green
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
N-dealkylation of an N-cyclopropylamine by horseradish peroxidase.: Fate of the cyclopropyl group
CL Shaffer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Mechanism-based inactivators as probes of cytochrome P450 structure and function
UM Kent et al.
CURRENT DRUG METABOLISM (2001)
Cytochromes P450 and metabolism of xenobiotics
P Anzenbacher et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2001)
Multi-state epoxidation of ethene by cytochrome P450: A quantum chemical study
SP de Visser et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Theoretical perspectives on proton-coupled electron transfer reactions
S Hammes-Schiffer
ACCOUNTS OF CHEMICAL RESEARCH (2001)
Hydroxylation of camphor by-reduced oxy-cytochrome P450cam: Mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes
R Davydov et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission
K Kassahun et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
Medium polarization and hydrogen bonding effects on compound I of Cytochrome p450: What kind of a radical is it really?
F Ogliaro et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Imidazole-ligated compound I intermediates: The effects of hydrogen bonding
MT Green
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
A model rebound mechanism of hydroxylation by cytochrome P450: Stepwise and effectively concerted pathways, and their reactivity patterns
F Ogliaro et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation
M Murray
CURRENT DRUG METABOLISM (2000)
Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394
LK Lightning et al.
BIOCHEMISTRY (2000)
Two-state reactivity as a new concept in organometallic chemistry
D Schroder et al.
ACCOUNTS OF CHEMICAL RESEARCH (2000)