Disposition of PCB 11 in Mice Following Acute Oral Exposure

PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung similar to muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.

Automated summary

Study on the distribution of PCB 11 and its metabolites in mice after oral exposure revealed that PCB 11 mainly accumulates in adipose tissue and lungs, with detected hydroxylated and sulfate metabolites in the liver. These findings lay the foundation for future toxicity studies on PCB 11.