A dynamic simulation model of a continuous horizontal fluidized bed dryer

The bottleneck of pharmaceutical continuous wet granulation lines may often be the drying stage. The introduction of horizontal fluidized beds is currently contemplated to solve this issue, inter alia. However, it would require an appropriate process control system to reach and maintain over time the targeted residual moisture of the product. To support the endeavor of both the process and control designs, this paper develops a dynamic model with lumped parameters of a continuous horizontal fluidized bed dryer equipped with a screw conveyor. To this end, the framework makes use of a two-phase tanks-in-series configuration, thus taking into account expected gas bypasses (bubbles) and product axial mixing. Array programming and vectorized operations on each tank reactor allow solving equations explicitly at a low computational cost. Simulation results for calcium carbonate granules in a laboratory scale dryer are consistent with fluidization, drying and continuous reactor fundamentals. (C) 2020 Elsevier Ltd. All rights reserved.

Automated summary

A dynamic model with lumped parameters of a continuous horizontal fluidized bed dryer equipped with a screw conveyor has been developed in this paper to support the endeavor of process and control designs. The simulation results for calcium carbonate granules in a laboratory scale dryer are consistent with fluidization, drying, and continuous reactor fundamentals.