Journal
CEREBRAL CORTEX
Volume 31, Issue 9, Pages 4386-4397Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhab093
Keywords
adult hippocampal neurogenesis; high-intensity intermittent training; spatial memory
Categories
Funding
- Education and Research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) [1111501004]
- Japan Society for the Promotion of Science (JSPS) [HFH27016]
- JSPS [18H04081, 18 K17790]
- Japan Science and Technology Agency (JST)-Mirai Program [JPMJMI19D5]
- Scientific Research on Innovative Areas: Next Generation Exercise Program for Developing Motivation, Body and Mind Performance [16H06405]
- Grants-in-Aid for Scientific Research [18H04081] Funding Source: KAKEN
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The study found that high-intensity intermittent training (HIIT) can enhance hippocampal memory and neurogenesis in rats, and promote hippocampal brain-derived neurotrophic factor (BDNF) signaling. After 4 weeks of training, HIIT also prolonged the time in the all-out exercise test and increased citrate synthase activity in skeletal muscle.
High-intensity intermittent (or interval) training (HIIT) has started to gain popularity as a time-effective approach to providing beneficial effects to the brain and to peripheral organs. However, it still remains uncertain whether HIIT enhances hippocampal functions in terms of neurogenesis and spatial memory due to unconsidered HIIT protocol for rodents. Here, we established the HIIT regimen for rats with reference to human study. Adult male Wistar rats were assigned randomly to Control, moderate-intensity continuous training (MICT; 20 m/min, 30 min/day, 5 times/week), and HIIT (60 m/min, 10 30-s bouts of exercise, interspaced with 2.5 min of recovery, 5 times/week) groups. The ratios of exercise time and volume between MICT and HIIT were set as 6:1 and 2:1-4:1, respectively. After 4 weeks of training, all-out time in the incremental exercise test was prolonged for exercise training. In skeletal muscle, the plantaris citrate synthase activity significantly increased only in the HIIT group. Simultaneously, both HIIT and MICT led to enhanced spatial memory and adult hippocampal neurogenesis (AHN) as well as enhanced protein levels of hippocampal brain-derived neurotrophic factor (BDNF) signaling. Collectively, we suggest that HIIT could be a time-efficient exercise protocol that enhances hippocampal memory and neurogenesis in rats and is associated with hippocampal BDNF signaling.
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