Magnetite nanoparticles anchored on graphene oxide loaded with doxorubicin hydrochloride for magnetic hyperthermia therapy

Magnetic hyperthermia therapy (MHT) is a highly promising therapeutic modality, mainly applied to deal with cancers and malignant tumors. To gain efficient magnetic hyperthermia therapy, magnetic nanoparticles (Fe3O4) with improved heating efficiency are necessary. In this work, magnetite nanoparticles anchored on graphene oxide (GO/Fe3O4) have been synthesized via chemical precipitation method, and anti-cancer drug have been introduced to form GO/Fe3O4 loaded with doxorubicin hydrochloride (GO/Fe3O4-DXR) composite nanoparticles. X-ray diffraction analysis has been carried out to characterized the crystal structure of GO/Fe3O4 nanoparticles with different mass ratios. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of doxorubicin hydrochloride (DRX) in GO/Fe3O4-DXR, while the structure of GO/Fe3O4 nanoparticles with different mass ratios are studied by Transmission electron microscopy (TEM). And the heating efficacy of GO/Fe3O4-DXR nano particles were. investigated suitable for magnetic hyperthermia therapy under safe alternating magnetic fields (80 kHz, 30 kA m(-1)). Besides, the DXR loading and release data of GO/Fe3O4-DXR have been tested via ultraviolet-visible spectroscopy (UVVIS) in presence of the AC field. The above characteristics conform to temperature requirements of magnetic materials on medical applications, which infers that GO/Fe3O4-DXR particles show promising talent as targeted drug carriers and thermoseeds in MHT.

Automated summary

This study synthesized magnetite nanoparticles anchored on graphene oxide and loaded them with an anti-cancer drug to create a promising carrier for magnetic hyperthermia therapy. The structure and heating efficiency of the nanoparticles were investigated, showing potential as targeted drug carriers and thermoseeds in MHT.