The good and bad of adipose tissue macrophage exosomes in obesity

Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk, which decreased inflammation and improved insulin signaling.

Automated summary

In a recent study, it was found that M2 polarized bone marrow-derived macrophages secrete exosomes containing miR-690 to improve glucose-insulin homeostasis in obese mice. This is achieved by reducing the expression of Nadk, which in turn decreases inflammation and enhances insulin signaling.