Journal
CELL HOST & MICROBE
Volume 29, Issue 5, Pages 675-677Publisher
CELL PRESS
DOI: 10.1016/j.chom.2021.04.012
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Funding
- Netherlands Organization for Scientific Research (NWO) through a Rubicon grant [019.193EN. 032]
- Deutsche Forschungsgemeinschaft [SPP 2141 (BE 6703/1-1)]
- European Research Council Consolidator award [865973]
- European Research Council (ERC) [865973] Funding Source: European Research Council (ERC)
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CASTs are unique mobile genetic elements that utilize CRISPR-Cas immune systems for RNA-guided DNA transposition, but their CRISPR arrays rarely match their chromosomal location. A recent study in Cell reveals the chromosomal homing mechanisms unique to different types of CAST, independent of the CRISPR arrays, helping to resolve this paradox.
CRISPR transposons (CASTs) represent unique mobile genetic elements that co-opted CRISPR-Cas immune systems for RNA-guided DNA transposition. However, CAST-encoded CRISPR arrays rarely match the CAST's chromosomal location. A recent publication in Cell helps resolve this paradox by revealing CRISPR-array-independent mechanisms of chromosomal homing unique to different CAST types.
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