Journal
CELL BIOCHEMISTRY AND FUNCTION
Volume 39, Issue 6, Pages 702-712Publisher
WILEY
DOI: 10.1002/cbf.3636
Keywords
autophagy; dentin-pulp complex; osteo-/odontoblastic differentiation; periapical lesion; pulpitis; tooth aging; tooth development
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Funding
- Guangdong Financial Fund for High-Caliber Hospital Construction [174-2018-XMZC-0001-03-0125/D-02]
- National Natural Science Foundation of China [81870737, 81972545, 81541153, 81771098]
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Autophagy is a conserved cellular process that plays important roles in maintaining homeostasis and integrity of the dentin-pulp complex, as well as in the pathogenesis of dental diseases. It is also involved in tooth development and aging.
Autophagy is an evolutionarily conserved cellular process, in which damaged organelles and proteins are engulfed in autophagic vesicles and subsequently fuse with lysosomes for degradation. Autophagy is widely involved in different physiologic or pathologic processes in human. Accumulating evidence indicates that autophagy operates as a critical quality control mechanism to maintain pulp homeostasis and structural integrity of the dentin-pulp complex. Autophagy is activated during stresses and is involved in the pathogenesis of pulpitis and periapical infection. Recent discoveries have also provided intriguing insights into the roles of autophagy in tooth development, pulp aging and stress adaptation. In this review, we provide an update on the multifaceted functions of autophagy in physiology and pathophysiology of tooth. We also discuss the therapeutic implications of autophagy modulation in diseases and the regeneration of dentin-pulp complex.
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