Journal
CARBOHYDRATE POLYMERS
Volume 268, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118192
Keywords
Breast cancer; Chitosan; Drug delivery; Chemotherapy drugs
Categories
Funding
- Natural Science Foundation of China [81760402, 81760390]
- Key R&D Program of Guangxi Science and Technology Department
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Chitosan, with its advantages of being non-toxic, non-immunogenic, and biocompatible, holds great potential as a drug delivery system for treating breast cancer.
Breast cancer (BC) is considered as one the most prevalent cancers worldwide. Due to its high resistance to chemotherapy and high probability of metastasis, BC is one of the leading causes of cancer-related deaths. The controlled release of chemotherapy drugs to the precise site of the tumor tissue will increase the therapeutic efficacy and decrease side effects of systemic administration. Among various drug delivery systems, natural polymers-based drug carriers have gained significant attention for cancer therapy. Chitosan, a natural polymer obtained by de-acetylation of chitin, holds huge potential for drug delivery applications because chitosan is nontoxic, non-immunogenic, biocompatible, chemically modifiable, and can be processed to form various formulations. In the current review, we will discuss the prospects and challenges of chitosan-based drug delivery systems in treating BC.
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