Journal
CARBOHYDRATE POLYMERS
Volume 257, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117636
Keywords
Long-lasting antibacterial; Ablation biofilms; Silver nanoparticles; Sulfated chitosan; Long-acting slow-release; Nanogel
Categories
Funding
- National Natural Science Foundation of China [51503131, 51703245]
- Natural Science Foundation of Jiangsu Province [BK20181377, BK20170733]
- Zhejiang Provincial Medical and Health Science and Technology Plan [2021KY073]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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The development of a multifunctional antibacterial agent AgNPs@CS/SCS, capable of generating silver nanoparticles in-situ and providing long-acting slow-release of Ag+, shows excellent antibacterial and biofilm ablation activity. It also exhibits superior antibacterial activity in the treatment of implant infections and good biocompatibility.
Development of multifunctional antibacterial agent with long-lasting antibacterial activity and biofilm ablation performance is significant for the effective treatment of bacterial infections. Here, by utilizing the electrostatic interaction between sulfonated chitosan (SCS) and Ag+ and chitosan (CS), and the sodium borohydride reduction method, a versatile antibacterial agent (AgNPs@CS/SCS) capable of generating silver nanoparticles (AgNPs) in-situ and long-acting slow-release Ag+ was developed. AgNPs@CS/SCS has a good physiological stability and can long-acting slow-release of Ag+ due to the pH-dependent Ag+ release behavior of AgNPs. Noteworthy, AgNPs@CS/SCS can exert both excellent short- and long-term antibacterial and biofilm ablation activity. Importantly, it also exhibits superior antibacterial activity in the treatment of implant infections, accompanied by good biocompatibility. Together, this study suggest that AgNPs@CS/CSC is indeed a versatile antibacterial agent, and is expected to provide an effective treatment modality for implant infections in the clinic settings.
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