Journal
CARBOHYDRATE POLYMERS
Volume 269, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.118222
Keywords
Bioprinting; Bioink; Agarose; Facial reconstruction; Nutrition channel network
Categories
Funding
- National Natural Science Foundation of China [81960416]
- Science and Technology Foundation of Guizhou Province [LH-[2017]-7199]
- Department of Science and Technology of Guizhou Province [[2020]6013]
- Department of Science and Technology of Guiyang City [2019-1-38]
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This study successfully constructed non-collapsing 3D structures using three polysaccharide hydrogel composites, which are beneficial for the construction of personalized, complex, and vascularized tissue-engineered anatomical faces.
Large, deep, complex, and severe tissue defects and deformities of the face are the problems encountered in clinical practice. Autologous tissue reconstruction or allograft face transplantation has been adopted but has problems such as blood supply difficulties, collateral damage, immune rejection, and ethical disputes. 3D bioprinting enables personalized tissue regeneration. However, simple hydrogels are prone to collapse during printing, are limited in size, and have poor shape and structure. The present study used three polysaccharide hydrogel composites of nanocellulose, agarose, and sodium alginate with seeded cells as bioinks and polyvinyl alcohol (PVA) as sacrificial material to construct the structures that did not collapse (characteristic parts, such as lips and nose). The nutrient network gradually formed a blood vessel-like structure. The hydrogels prepared using these three polysaccharides have great potential in the construction of personalized, complex, and vascularized tissue-engineered anatomical faces and provide a new strategy for autologous full face reconstruction.
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