4.8 Article

Artificial intelligence for clinical oncology

Journal

CANCER CELL
Volume 39, Issue 7, Pages 916-927

Publisher

CELL PRESS
DOI: 10.1016/j.ccell.2021.04.002

Keywords

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Funding

  1. NIH [NIH-USA U24CA194354, NIH-USA U01CA190234, NIH-USA U01CA209414, NIHUSA R35CA22052, NIH-K08:DE030216]
  2. European Union -European Research Council [866504]
  3. Radiological Society of North America [RSCH2017]
  4. European Research Council (ERC) [866504] Funding Source: European Research Council (ERC)

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This article discusses the challenges faced in clinical oncology, proposes a pathway for narrow-task AI applications in clinical cancer care, and emphasizes the importance of clinical validity, utility, and usability.
Clinical oncology is experiencing rapid growth in data that are collected to enhance cancer care. With recent advances in the field of artificial intelligence (AI), there is now a computational basis to integrate and synthesize this growing body of multi-dimensional data, deduce patterns, and predict outcomes to improve shared patient and clinician decision making. While there is high potential, significant challenges remain. In this perspective, we propose a pathway of clinical cancer care touchpoints for narrow-task AI applications and review a selection of applications. We describe the challenges faced in the clinical translation of AI and propose solutions. We also suggest paths forward in weaving AI into individualized patient care, with an emphasis on clinical validity, utility, and usability. By illuminating these issues in the context of current AI applications for clinical oncology, we hope to help advance meaningful investigations that will ultimately translate to real-world clinical use.

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