Journal
CANCER BIOMARKERS
Volume 31, Issue 3, Pages 255-261Publisher
IOS PRESS
DOI: 10.3233/CBM-210061
Keywords
Acute myeloid leukemia; ISG20; survival times; prognosis; interferon
Categories
Funding
- Sichuan department of science and technology [20YYJC0940, 2017LZXNYD-Z06]
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The study revealed that high expression of ISG20 serves as a poor prognostic indicator in AML patients, being related to overall survival time.
BACKGROUND: Acute myeloid leukemia (AML) is one of the most malignant hematopoietic system diseases. Interferon stimulated exonuclease gene 20 (ISG20) is a protein induced by interferons or double-stranded RNA, which is associated with poor prognosis in several malignant tumors. However its expression in AML is unknown. OBJECTIVE: To explore the expression of ISG20 in AML and its prognostic significance. METHODS: The expression of ISG20 in AML patients was analyzed by GEPIA database, detected by qRT-PCR and their prognosis was followed-up. Chi-square test was used to identify the association between ISG20 expression and clinical characteristics of the patients. Kaplan-Meier analysis was performed to draw survival curves and Cox regression analysis to confirm the independent prognostic factors of AML patients. RESULTS: Kaplan-Meier analysis revealed that whether to receive treatment, karyotype, and ISG20 expression were related to overall survival time of AML patients (P < 0.05). Cox regression analysis showed that whether to receive treatment (HR = 0.248, 95% CI = 0.076-0.808, P = 0.021) and high expression of ISG20 (HR = 4.266, 95% CI = 1.118-16.285, P = 0.034) were independent unfavorable prognostic factors for AML patients. CONCLUSION: The high expression of ISG20 acts as a poor prognosis indicator in AML patients.
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