Society Guidelines 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults

The 2021 guidelines primary panel selected clinically relevant questions and produced updated recommendations, on the basis of important new findings that have emerged since the 2016 guidelines. In patients with clinical atherosclerosis, abdominal aortic aneurysm, most patients with diabetes or chronic kidney disease, and those with low-density lipoprotein cholesterol >= 5 mmol/L, statin therapy contin ues to be recommended. We have introduced the concept of lipid/lipoprotein treatment thresholds for intensifying lipid-lowering therapy with nonstatin agents, and have identified the secondary prevention patients who have been shown to derive the largest benefit from intensification of therapy with these agents. For all other patients, we emphasize risk assessment linked to lipid/lipoprotein evaluation to optimize clinical decision-making. Lipoprotein(a) measurement is now recommended once in a patient's lifetime, as part of initial lipid screening to assess cardiovascular risk. For any patient with triglycerides > 1.5 mmol/L, either non-high-density lipoprotein cholesterol or apolipoprotein B are the preferred lipid parameter for screening, rather than low-density lipoprotein cholesterol. We provide updated recommendations regarding the role of coronary artery calcium scoring as a clinical decision tool to aid the decision to initiate statin therapy. There are new recommendations on the preventative care of women with hypertensive disorders of pregnancy. Health behaviour modification, including regular exercise and a heart-healthy diet, remain the cornerstone of cardiovascular disease prevention. These guidelines are intended to provide a platform for meaningful conversation and shared-decision making between patient and care provider, so that individual decisions can be made for risk screening, assessment, and treatment.

Automated summary

The 2021 guidelines provide updated recommendations for patients with clinical atherosclerosis, abdominal aortic aneurysm, diabetes, chronic kidney disease, and high LDL cholesterol levels, emphasizing statin therapy. The guidelines introduce lipid/lipoprotein treatment thresholds and recommend Lipoprotein(a) measurement once in a patient's lifetime for cardiovascular risk assessment. Additionally, there are new recommendations for preventative care for women with hypertensive disorders of pregnancy. The guidelines highlight the importance of health behavior modifications as the cornerstone of cardiovascular disease prevention and aim to facilitate meaningful conversations and shared decisions between patients and care providers.