Mitochondria Homeostasis and Vascular Medial Calcification

Vascular calcification occurs highly prevalent, which commonly predicts adverse cardiovascular events. The pathogenesis of calcification, a complicated and multifactorial process, is incompletely characterized. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detrimental in the vascular smooth muscle cells (VSMCs) calcification. This review summarizes the role of mitochondrial dysfunction and metabolic reprogramming in vascular calcification, and indicates that metabolic regulation may be a therapeutic target in vascular calcification.

Automated summary

Vascular calcification is highly prevalent and predicts adverse cardiovascular events. The pathogenesis of calcification is complex and incompletely characterized, with evidence showing that mitochondrial dysfunction may play a key role in vascular smooth muscle cells calcification. Metabolic regulation could be a potential therapeutic target in vascular calcification.