Letter to the Editor: Significant mutation enrichment in inverted repeat sites of new SARS-CoV-2 strains

Summary: By analyzing high-frequency mutations of SARS-CoV-2 and their overlay with IR and CpG island loci, this study found that hot-spot mutations of the virus are significantly enriched within these regions. The hypothesis is that hypermethylation of CpG islands may decrease the transcription of viral ORFs and therefore limit the progression of the disease.