Journal
BRIEFINGS IN BIOINFORMATICS
Volume 22, Issue 5, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbab129
Keywords
SARS-CoV-2; mutations; inverted repeats
Funding
- Czech Science Foundation [18-15548S, 18-18699S]
- ERDF [CZ.02.1.01/0.0/0.0/15_003/0000477]
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The study found that mutations in the new SARS-CoV-2 strains are significantly enriched in inverted repeat loci.
In a recently published paper, we have found that SARS-CoV-2 hot-spot mutations are significantly associated with inverted repeat loci and CG dinucleotides. However, fast-spreading strains with new mutations (so-called mink farm mutations, England mutations and Japan mutations) have been recently described. We used the new datasets to check the positioning of mutation sites in genomes of the new SARS-CoV-2 strains. Using an open-access Palindrome analyzer tool, we found mutations in these new strains to be significantly enriched in inverted repeat loci.
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