Journal
BRAIN IMAGING AND BEHAVIOR
Volume 10, Issue 3, Pages 719-729Publisher
SPRINGER
DOI: 10.1007/s11682-015-9439-8
Keywords
Gray matter volume; Functional connectivity; Internet gaming disorder; Prefrontal cortex-striatal circuits
Categories
Funding
- Project for the National Key Basic Research and Development Program (973) [2014CB543203, 2011CB707700, 2012CB518501]
- National Natural Science Foundation of China [81401478, 81401488, 81227901, 81271644, 81271546, 81101036, 81101108, 31200837, 81301281]
- Natural Science Basic Research Plan in Shaanxi Province of China [2014JQ4118]
- Fundamental Research Funds for the Central Universities [8002-72125760, 8002-72135767, 8002-72145760]
- Natural Science Foundation of Inner Mongolia [2012MS0908]
- China Post- doctoral Science Foundation [2014 M552416]
Ask authors/readers for more resources
Internet Gaming Disorder (IGD) among adolescents has become an important public concern and gained more and more attention internationally. Recent studies focused on IGD and revealed brain abnormalities in the IGD group, especially the prefrontal cortex (PFC). However, the role of PFC-striatal circuits in pathology of IGD remains unknown. Twenty-five adolescents with IGD and 21 age- and gender-matched healthy controls were recruited in our study. Voxel-based morphometric (VBM) and functional connectivity analysis were employed to investigate the abnormal structural and resting-state properties of several frontal regions in individuals with online gaming addiction. Relative to healthy comparison subjects, IGD subjects showed significant decreased gray matter volume in PFC regions including the bilateral dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and the right supplementary motor area (SMA) after controlling for age and gender effects. We chose these regions as the seeding areas for the resting-state analysis and found that IGD subjects showed decreased functional connectivity between several cortical regions and our seeds, including the insula, and temporal and occipital cortices. Moreover, significant decreased functional connectivity between some important subcortical regions, i.e., dorsal striatum, pallidum, and thalamus, and our seeds were found in the IGD group and some of those changes were associated with the severity of IGD. Our results revealed the involvement of several PFC regions and related PFC-striatal circuits in the process of IGD and suggested IGD may share similar neural mechanisms with substance dependence at the circuit level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available