Journal
BMC PEDIATRICS
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12887-021-02625-z
Keywords
Celiac disease; Potential celiac disease; Pediatrics; Biopsy
Categories
Funding
- Department of Pediatrics, Washington University School of Medicine
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A subset of patients initially with negative biopsy for celiac disease later develop histopathologic celiac disease, with slower progression in some cases. Regular reassessment is recommended for children with serological signs of celiac disease despite normal small bowel biopsy results.
Background A subset of patients with serology suggesting celiac disease have an initially negative biopsy but subsequently develop histopathologic celiac disease. Here we characterize patients with potential celiac disease who progress to celiac disease. Methods We performed a retrospective analysis of children (0-18 years of age) with biopsy-confirmed celiac disease seen at St. Louis Children's Hospital between 2013 and 2018. Results Three hundred sixteen of 327 (96%) children with biopsy-confirmed celiac disease were diagnosed on initial biopsy. The 11 children with potential celiac disease who progressed to celiac disease had lower anti-tissue transglutaminase (anti-TTG IgA) concentrations (2.4 (1.6-5) X upper limit of normal (ULN) vs. 6.41 (3.4-10.5) X ULN) at time of first biopsy. Their median anti-TTG IgA concentrations rose from 2.4 (1.6-5) X ULN to 3.6 (3.1-9.2) X ULN between biopsies. Conclusions Four percent of biopsy confirmed celiac patients initially had a negative biopsy, but later developed histopathologic celiac disease. This is likely an underestimate as no surveillance algorithm was in place. We recommend repeat assessment in children whose serology suggests celiac disease despite normal small bowel biopsy.
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