C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

BackgroundStaphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and is associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. aureus bacteraemia would aid clinicians in targeting patients that benefit from expedited investigations and escalated care.MethodsIn this prospective observational cohort study, we aimed to identify risk factors associated with a complicated infection in community-onset S. aureus bacteraemia. Potential risk factors were collected from electronic medical records and included: - patient demographics, symptomology, portal of entry, and laboratory results.ResultsWe identified several potential risk factors using univariate analysis. In a multiple logistic regression model, age, haemodialysis, and entry point from a diabetic foot ulcer were all significantly protective against complications. Conversely, an unknown entry point of infection, an entry point from an indwelling medical device, and a C-reactive protein concentration of over 161mg/L on the day of admission were all significantly associated with complications.ConclusionsWe conclude that several factors are associated with complications including already conducted laboratory investigations and portal of entry of infection. These factors could aid the triage of at-risk patients for complications of S. aureus bacteraemia.

Automated summary

Age, hemodialysis, and entry point from a diabetic foot ulcer were found to be protective factors against complications, while unknown entry point of infection, an entry point from an indwelling medical device, and high C-reactive protein concentration on admission day were significantly associated with complications. These factors can help identify at-risk patients for complications of S. aureus bacteraemia.