Journal
BLOOD
Volume 137, Issue 15, Pages 1988-1990Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2020010541
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- Rocket Pharmaceuticals
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The study demonstrates that iPSCs derived from patients with ADH5/ALDH2 deficiency fail to generate hematopoietic progenitors.
In this issue of Blood, Mu et al show that induced pluripotent stem cells (iPSCs) derived from patients with novel inherited bone marrow failure syndrome (IBMFS), alcohol dehydrogenase 5 (ADH5)/aldehyde dehydrogenase 2 (ALDH2) deficiency, fail to produce hematopoietic progenitors.
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