SPARCing the clot

In this issue of Blood, Shahneh et al reveal important functions of regulatory T cells (Tregs) in thrombus resolution in a mouse model.(1) Deep vein thrombosis (DVT) is a major cause of global morbidity and mortality. Despite the use of anticoagulants, vasoactive drugs, and physical clot removal techniques, DVT still causes permanent disability and mortality. Resolving the clot is difficult, and nonresolved clots can cause long-term pathologies, including postthrombotic syndrome and chronic thromboembolic pulmonary hypertension.(2)

Automated summary

Tregs play important roles in thrombus resolution in a mouse model, while deep vein thrombosis remains a major global health issue with difficult clot resolution and potential long-term pathologies.