4.7 Editorial Material

PML-RARα: changing myeloid networks

Related references

Note: Only part of the references are listed.
Article Hematology

A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia

Yun Tan et al.

Summary: The activation function of PML/RAR alpha through recruiting P300 and HDAC1 and forming super-enhancers, and its synergistic effects with all-trans retinoic acid and arsenic trioxide in controlling super-enhancer-associated PML/RAR alpha-regulated targets in APL cells are highlighted. The study demonstrated the necessity of the PML/RAR alpha-activated target gene GFI1 for maintaining APL cells and the interplay between GFI1 and PML/RAR alpha in coregulating target genes on chromatin. Genomic insight into the dual role of fusion transcription factors in transcriptional deregulation to drive leukemia development is provided, emphasizing the importance of globally dissecting regulatory circuits.

BLOOD (2021)

Article Biochemistry & Molecular Biology

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

Rihab Nasr et al.

NATURE MEDICINE (2008)

Article Multidisciplinary Sciences

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARα

MJ Walter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Genetics & Heredity

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

RE Person et al.

NATURE GENETICS (2003)