4.7 Editorial Material

PML-RARα: changing myeloid networks

Journal

BLOOD
Volume 137, Issue 11, Pages 1439-1440

Publisher

AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2020008849

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The novel cooperative effects between PML/RARα and GFI1 were identified to underlie the aberrant cell fate decisions characteristic of APL.
In this issue of Blood, Tan et al identify novel cooperative effects of the promyelocytic leukemia/retinoic acid receptor-alpha (PML/RAR alpha) chimeric fusion and the growth factor independent-1 (GFI1) transcriptional repressor that underlie aberrant cell fate decisions characteristic of acute promyelocytic leukemia (APL).(1)

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