FGF-23: a novel actor in stem cell mobilization

In this issue of Blood, Ishii et al(1) identify a novel role for fibroblast growth factor 23 (FGF-23), an osteocyte-derived hormone that regulates phosphate metabolism, in granulocyte colony-stimulating factor (G-CSF)-stimulated mobilization of hematopoietic stem and progenitor cells (HSPCs).

Automated summary

This study highlights the novel role of FGF-23 in G-CSF-stimulated mobilization of HSPCs, shedding light on the connection between phosphate metabolism and hematopoietic stem cells.