Journal
BIOSENSORS & BIOELECTRONICS
Volume 177, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2021.112966
Keywords
Sensitivity; Electrochemical sensor; Graphitic carbon; Voltammetry sensing
Categories
Funding
- NSF [MRI1531664, 1728051]
- Gordon and Betty Moore Foundation [GBMF 4838]
- U.S. DOE Office of Science Facility, at Brookhaven National Laboratory (BNL) [DE-SC0012704]
- Simons Collaboration on the Global Brain [542997]
- Pew Scholarship in the Biomedical Sciences
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1728051] Funding Source: National Science Foundation
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The sensitivity of substrate-supported nano-graphitic micro-sensors in response to dopamine was found to increase linearly with the inverse of the upper potential limit (UPL) in voltammetry experiments. This unexpected dependence was attributed to the UPL-induced electrostatic force that influences the steady-state number of dopamine molecules on the sensor surface, providing a new strategy for enhancing the performance of planar electrochemical micro-sensors.
Microscopic interactions between electrochemical sensors and biomolecules critically influence the sensitivity. Here, we report an unexpected dependence of the sensitivity on the upper potential limit (UPL) in voltammetry experiments. In particular, we find that the sensitivity of substrate-supported nano-graphitic micro-sensors in response to dopamine increases almost linearly with the inverse of UPL in voltammetry experiments with rapid potential sweeps. Our experiments and multi-physics simulations reveal that the main cause behind this phenomenon is the UPL-induced electrostatic force that influences the steady-state number of dopamine molecules on the sensor surface. Our findings illustrate a new strategy for enhancing the performance of planar electrochemical micro-sensors.
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