Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 44, Issue 9, Pages 1965-1974Publisher
SPRINGER
DOI: 10.1007/s00449-021-02578-8
Keywords
Aureobasidium pullulans; Liamocins; Polymalic acid; Waste gluconate mother liquor; Waste xylose mother liquor
Funding
- National Natural Science Foundation of China [31871783, 31571816]
- Fundamental Research Funds for the Central Universities [XDJK2018AC002]
- Chongqing Social and People's Livelihood Guarantee Special Program [cstc2016shmszx80075]
- National High Technology Research and Development Program of China (863 Program) [2015AA021005]
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The study investigated the coproduction of PMA and liamocins from waste by-products from the xylitol and gluconate industries, showing that waste xylose mother liquor could be used as a cost-effective feedstock without pretreatment. High titers of PMA and liamocins were obtained in batch fermentation, with economic assessment revealing the process to be economically viable and sustainable.
The coproduction of polymalic acid (PMA) and liamocins, two important metabolites secreted by Aureobasidium pullulans, from two waste by-products from the xylitol and gluconate industries was investigated in shake flasks and fermentors, confirming that waste xylose mother liquor (WXML) could be utilized as an economical feedstock without any pretreatment. Gluconate could strengthen carbon flux and NADPH supply for the synergetic biosynthesis of PMA and liamocins. High PMA and liamocin titers of 82.9 +/- 2.1 and 28.3 +/- 2.7 g/L, respectively, were obtained from the coupled WXML and waste gluconate mother liquor (WGML) in batch fermentation, with yields of 0.84 and 0.25 g/g, respectively. These results are comparable to those obtained from renewable feedstocks. Economic assessment of the process revealed that PMA and liamocins could be coproduced from two by-products at costs of $1.48/kg or $0.67/kg (with liamocins credit), offering an economic and sustainable process for the application of waste by-products.
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