4.7 Article

Structurally diverse alkaloids from Buxus sempervirens with cardioprotective activity

Journal

BIOORGANIC CHEMISTRY
Volume 109, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2021.104753

Keywords

Buxus; Buxus sempervirens; Buxus alkaloid; Cardioprotective effect

Funding

  1. National Natural Science Foundation of China [31870330, 81403050, 81773869, 81503359]
  2. Analytical and Testing Center of Huazhong University of Science and Technology (HUST)

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The study identified 17 Buxus alkaloids from the twigs and leaves of Buxus sempervirens, including 12 new ones. These novel alkaloids exhibit unique structures and bioactivities compared to previously known compounds.
Extensive phytochemical study of the methanol extract of twigs and leaves of Buxus sempervirens resulted in the identification of 17 Buxus alkaloids, including 12 new ones, namely buxusemines A-L (1-12). Their structures were delineated by detailed analysis of the HRESIMS and NMR data, as well as quantum chemical NMR calculations. Buxusemine A (1) represents the second Buxus alkaloid with a unique spiro[4.6]undecatriene moiety, buxusemines B-C (2-3) are a rarely occurring class of Buxus alkaloids featured with an additional five-membered ring through the ether or lactone linkage between C-10 and C-23, and buxusemines D-F (4-6) are another rare type of Buxus alkaloids with an epoxy motif. In the assessment of their bioactivities, buxusemine F (6) and buxanoldine (17) displayed more potent protective effects than the positive control cyclovirobuxinum D in the doxorubicin-induced cardiac injury model.

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