Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 137, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111383
Keywords
Asthma; Therapeutic strategy; Traditional Chinese medicine; Active ingredients; Mechanism
Funding
- National Natural Science Foundation of China [81774074, 81704154]
- Shanghai Science and Technology Commission [17401930300, 18401971300]
- China Association for Science and Technology [2018QNRC001]
- China National Key Research and Development Plan Project [2018YFC1708300]
- innovative research team of highlevel local university in Shanghai
- Innovative research team of highlevel local universities in Shanghai-Clinical and basic research on the prevention and treatment of some inflammatory diseases by integrative medicine
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Active ingredients from Chinese medicine have multilevel effects on asthma by regulating the immunologic equilibrium mechanism or signaling pathways, giving them great clinical value. However, the safety and functional mechanism of these ingredients still must be further determined.
Although considerable advance has been made in diagnosing and treating, asthma is still a serious public health challenge. Traditional Chinese medicine (TCM) is an effective therapy of complementary and alternative med-icine. More and more scientific evidences support the use of TCM for asthma treatment, and active ingredients from Chinese medicine plants are becoming a hot issue. Purpose of review: To summarize the frontier knowledge on the function and underlying mechanisms of the active ingredients in asthma treatments and provide a fully integrated, reliable reference for exploring innovative treatments for asthma. Methods: The cited literature was obtained from the PubMed and CNIK databases (up to September 2020). Experimental studies on the active ingredients of Chinese medicine and their therapeutic mechanisms were identified. The key words used in the literature retrieval were asthma and traditional Chinese medicine or Chinese herbal medicine. The literature on the active ingredients was then screened manually. Results: We summarized the effect of these active ingredients on asthma, primarily including the effect through which these ingredients can regulate the immunologic equilibrium mechanism by acting on a number of sig-nalling pathways, such as Notch, JAK-STAT-MAPK, adiponectin-iNOS-NF-kappa B, PGD2-CRTH2, PI3K/AKT, Keap1-Nrf2/HO-1, T-bet/Gata-3 and Foxp3-ROR gamma t, thereby regulating the progression of asthma. Conclusion: The active ingredients from Chinese medicine have multilevel effects on asthma by regulating the immunologic equilibrium mechanism or signalling pathways, giving them great clinical value. However, the safety and functional mechanism of these ingredients still must be further determined.
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