4.5 Review

Stimuli-activatable nanomaterials for phototherapy of cancer

Journal

BIOMEDICAL MATERIALS
Volume 16, Issue 4, Pages -

Publisher

IOP Publishing Ltd
DOI: 10.1088/1748-605X/abfa6e

Keywords

cancer treatment; photodynamic therapy; photothermal therapy; intelligent nanomaterials; stimuli-responsiveness

Funding

  1. National Natural Science Foundation of China [31900990]
  2. Youth Natural Science Fund of Jiangsu Province [BK20200977, BK20200972]
  3. Nantong Municipal Science and Technology Project [JC2019103]
  4. Jiangsu College Students'Innovation and Entrepreneurship Training Program [202010304124Y, 201910304124Y]
  5. Basic Research Program of Shenzhen, Science and Technology Development Fund [JCYJ20180227175420974]

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Phototherapy, including PTT and PDT, has gained attention for cancer treatment due to its non-invasive nature. Researchers are actively developing stimuli-activatable nanomaterials to enhance the therapeutic effects of phototherapy and minimize side effects.
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT), as non-invasive therapy approaches, have gained accumulated attention for cancer treatment in past years. PTT and PDT can generate local hyperthermia effects and reactive oxygen species (ROS) respectively, for tumor eradication. To improve the therapeutic performance while minimizing the reverse side effects of phototherapy, extensive efforts have been devoted to developing stimuli-activatable (e.g. pH, redox, ROS, enzyme, etc) nanomaterials for tumor-specific delivery/activation of the phototherapeutics. In this review, we first overviewed the recent advances of the engineered stimuli-responsive nanovectors for the phototherapy of cancer. We particularly summarized the progress of stimuli-activatable nanomaterials-based combinatory therapy strategies for augmenting the performance of phototherapy. We further discuss challenges for the clinical translation of nanomaterials-based phototherapy.

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