Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis

Background Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis for five cannulation angles. With respect to the inflow cannula axis directed towards the mitral valve, the other angles were 25 degrees and 20 degrees towards the septum and 20 degrees and 30 degrees towards the free wall. Results Inflow cannula angulation towards the free wall resulted in longer blood residence time within the ventricle, slower ventricular washout and reduced pulsatility indices along the septal wall. Based on the model, the ideal inflow cannula alignment to reduce the risk of thrombosis was angulation towards the mitral valve and up to parallel to the septum, avoiding the premature clearance of incoming blood. Conclusions This study indicates the potential effects of inflow cannulation angles and may guide optimised implantation configurations; however, the ideal approach will be influenced by other patient factors and is suspected to change over the course of support.

Automated summary

The study reveals the potential impact of inflow cannulation angles on thrombosis risk, suggesting that ideal inflow cannula alignment is towards the mitral valve and parallel to the septum. However, the optimal approach may vary depending on other patient factors and may change during the course of LVAD support.