Epigenetic transgenerational inheritance, gametogenesis and germline development

One of the most important developing cell types in any biological system is the gamete (sperm and egg). The transmission of phenotypes and optimally adapted physiology to subsequent generations is in large part controlled by gametogenesis. In contrast to genetics, the environment actively regulates epigenetics to impact the physiology and phenotype of cellular and biological systems. The integration of epigenetics and genetics is critical for all developmental biology systems at the cellular and organism level. The current review is focused on the role of epigenetics during gametogenesis for both the spermatogenesis system in the male and oogenesis system in the female. The developmental stages from the initial primordial germ cell through gametogenesis to the mature sperm and egg are presented. How environmental factors can influence the epigenetics of gametogenesis to impact the epigenetic transgenerational inheritance of phenotypic and physiological change in subsequent generations is reviewed. Summary sentence How environmental factors can influence the epigenetics of gametogenesis to impact the epigenetic transgenerational inheritance of phenotypic and physiological change in subsequent generations is reviewed.

Automated summary

The development of gametes (sperm and egg) is crucial in transmitting optimized physiological adaptations and phenotypes to subsequent generations. Environmental factors actively regulate epigenetics, impacting the physiology and phenotype of cellular and biological systems. The integration of genetics and epigenetics is essential for developmental biology systems at the cellular and organism level.