Journal
EPIGENETICS
Volume 12, Issue 1, Pages 19-26Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15592294.2016.1252891
Keywords
DNA methylation; endometrial cancer; FIGO grade; prognosis
Funding
- Lions Cancer Foundation, Uppsala
- Nyckelfonden, Orebro
- Cancer-forskningsfonden, Umea
- Swedish Research Council
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Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.
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