Journal
BIOLOGICAL CHEMISTRY
Volume 402, Issue 11, Pages 1385-1395Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2021-0171
Keywords
bone regeneration; (meth)acrylation; protein binding; release; sulfation; wound healing
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [59307082 -TRR67]
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The review discusses recent achievements in chemically modified GAG and collagen/GAG-based coatings and hydrogels, emphasizing the regulatory role of GAG in tissue regeneration and their potential as promising candidates for controlling cellular responses.
Tissue regeneration is regulated by the cellular microenvironment, e.g. the extracellular matrix. Here, sulfated glycosaminoglycans (GAG), are of vital importance interacting with mediator proteins and influencing their biological activity. Hence, they are promising candidates for controlling tissue regeneration. This review addresses recent achievements regarding chemically modified GAG as well as collagen/GAG-based coatings and hydrogels including (i) chemical functionalization strategies for native GAG, (ii) GAG-based biomaterial strategies for controlling cellular responses, (iii) (bio)chemical methods for characterization and iv) protein interaction profiles and attained tissue regeneration in vitro and in vivo. The potential of GAG for bioinspired, functional biomaterials is highlighted.
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