Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue

COVID-19 leads to severe respiratory problems, but also to long-COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long-COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS). The pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus. These processes could be mitigated by phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin.

Automated summary

COVID-19 not only causes severe respiratory problems but also leads to long-COVID syndrome, with symptoms including cognitive dysfunction and fatigue, particularly brain fog. The pathogenesis of brain fog in these illnesses is currently unknown, but may involve neuroinflammation caused by mast cells, which could be mitigated by the phytosomal formulation of the natural flavonoid luteolin.