Journal
BIOCHEMICAL PHARMACOLOGY
Volume 187, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2020.114350
Keywords
P2X; Extracellular ATP; Cancer; Proliferation; Ion channels
Categories
Funding
- Italian Association for Cancer Research (AIRC) [IG 13025, IG 18581, IG 22883]
- Ministry of Education of Italy [8YTNWC, RBAP11FXBC]
- Italian Ministry of Health [RF2011-02348435]
- University of Ferrara
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Ion channels, especially P2X receptors, play crucial roles in tumor development, closely related to extracellular ATP, and could be key regulators of tumor growth.
It is increasingly appreciated that ion channels have a crucial role in tumors, either as promoters of cancer cell growth, or modulators of immune cell functions, or both. Among ion channels, P2X receptors have a special status because they are gated by ATP, a common and abundant component of the tumor microenvironment. Furthermore, one P2X receptor, i.e. P2X7, may also function as a conduit for ATP release, thus fuelling the increased extracellular ATP level in the tumor interstitium. These findings show that P2X receptors and extracellular ATP are indissoluble partners and key regulators of tumor growth, and suggest the exploitation of the extracellular ATP-P2X partnership to develop innovative therapeutic approaches to cancer.
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